DESCRIPTION

A combination antibiotic called Ofril-CV Tablet (Cefpodoxime Proxetil 200 mg + Clavulanic Acid 125 mg) is used to treat a variety of bacterial infections. Potassium clavulanate increases the potency of cefpodoxime proxetil, a broad-spectrum cephalosporin, by blocking beta-lactamase enzymes, which prevents the formation of bacterial cell walls. Skin infections, urinary tract infections, and respiratory tract infections can all be effectively treated with this combination. Usually, it is administered when other antibiotics might not work as well.

INDICATION

• Bronchitis : Ofril-CV Tablet is characterized by inflammation and enlargement of the bronchial tubes, which control lung airflow. Bacterial bronchitis is treated with Ofril-CV Tablet (Cefpodoxime Proxetil 200 mg + Clavulanic Acid 125 mg). Additionally, it is used to treat recurrent episodes of bronchitis that often follow early recovery and abrupt exacerbation of chronic bronchitis, a persistent form of bronchitis.

• Gonococcal Infection : Both men and women can contract gonorrhea, a sexually transmitted infection (STI) brought on by the Neisseria gonorrhoea bacteria. Without the use of a condom or other barrier technique, it spreads during anal, oral, or vaginal sex. The gonococcal infection is treated with Ofril-CV Tablet (Cefpodoxime Proxetil 200 mg + Clavulanic Acid 125 mg).

• Sinusitis : The swelling of the membranes lining your nose and the sinuses around it is known as sinusitis. Bacteria are frequently the culprit, however viruses and fungi can also be involved. A stuffy nose and pressure or soreness behind your eyes, nose, cheekbones, or forehead are possible symptoms. For bacterial sinusitis, the Ofril-CV Tablet (Cefpodoxime Proxetil 200 mg + Clavulanic Acid 125 mg) provide treatment in three to eight weeks.

• Community acquired pneumonia : Community-acquired pneumonia: Lung infections that are contracted outside of a hospital are referred to as community-acquired pneumonia (CAP). Both bacteria and viruses can cause CAP. CAP brought on by bacteria is treated with Ofril-CV Tablet (Cefpodoxime Proxetil 200 mg + Clavulanic Acid 125 mg).

• Pharyngitis/Tonsillitis : Both tonsillitis and pharyngitis are infections that result in tonsil and throat swelling and discomfort. Pharyngotonsillitis is the term used to describe an infection that affects both the tonsils and the throat. In order to treat tonsillitis, pharyngitis, and/or pharyngotonsillitis, the Ofril-CV Tablet (Cefpodoxime Proxetil 200 mg + Clavulanic Acid 125 mg) is utilized.
  
   

• Urinary Tract Infection : Urinary tract infections (UTIs) can affect any component of your urinary system, including the kidneys, bladder, ureters, or urethra. Women are more susceptible to UTIs, which are the most prevalent illness in humans. Bacteria, as well as occasionally viruses or fungus, are the cause of UTIs. Ofril-CV Tablet (200 mg of cefpodoxime proxetil plus 125 mg of clavulanic acid) is used to treat bacterial urinary tract infections.
   

• Skin and Skin Structure Infection : When bacteria infiltrate the skin and the structures that support it, infections of the skin and soft tissues result. Ofril-CV Tablet (200 mg of cefpodoxime proxetil plus 125 mg of clavulanic acid) is used to treat bacterial abscesses as well as other skin diseases.

• Acute otitis media : Common in newborns and young children, otitis media (AOM) is an infection of the middle ear, or the space behind the eardrum. Acute bacterial otitis media is treated with Ofril-CV Tablet (Cefpodoxime Proxetil 200 mg + Clavulanic Acid 125 mg).

MECHANISM OF ACTION

Cefpodoxime Proxetil: This is a prodrug that gets converted to cefpodoxime in the body. It belongs to the cephalosporin class of antibiotics, which inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This disrupts the formation of the cell wall, leading to cell lysis and death of the bacteria.
 

Potassium Clavulanate: This is a beta-lactamase inhibitor that protects cefpodoxime from degradation by certain enzymes produced by resistant bacteria. By inhibiting these beta-lactamases, clavulanate enhances the effectiveness of cefpodoxime, allowing it to target a broader range of bacteria, including those that would normally be resistant.

DRUG INTERACTIONS

Drug-Drug Interactions: Cefpodoxime + Clavulanic acid may have interaction with anticoagulants (warfarin), anti-gout (probenecid), diuretics (furosemide), and vitamin supplements (calcium/vitamin D).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interaction: Inform your doctor if you have colitis (inflammation in the lining of the colon), seizures, dialysis, kidney and liver dysfunction.

.

SIDE EFFECTS OF OFRIL-CV TABLET

Major & minor side effects for Ofril- CV  Tablet

• Diarrhoea
• Acid or sour stomach
• Headache
• Nausea and vomiting

PRECAUTION 

When using Ofril-CV Tablet (Cefpodoxime Proxetil 200 mg + Clavulanic Acid 125 mg) inform your healthcare provider about any allergies, particularly to penicillins or cephalosporins, to avoid potential reactions. Monitor for gastrointestinal side effects, such as diarrhea, which could indicate antibiotic-associated colitis. Caution is advised for patients with renal impairment, as dosage adjustments may be required. Always complete the prescribed course to prevent antibiotic resistance, even if symptoms improve.

DISCLAIMER

The information on this website is provided for general informational purposes only and is not medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.